X0508 4 2026-01-26 0 0001157601 MADRIGAL PHARMACEUTICALS, INC. MDGL 0002001571 Huntsman Carole C/O MADRIGAL PHARMACEUTICALS, INC. 200 BARR HARBOR DRIVE, SUITE 200 WEST CONSHOHOCKEN PA 19428 0 1 0 0 Chief Commercial Officer 1 Common Stock 2026-01-26 4 S 0 340 492.42 D 9692 D Common Stock 2026-01-26 4 S 0 570 494.59 D 9122 D The sale reported on this line represents the number of shares sold by the Issuer on behalf of the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. This sale was automatic and not at the discretion of the Reporting Person. This sale was made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 5, 2024. /s/ Mardi Dier, as Attorney-in-Fact 2026-01-26