X0508 4 2026-01-26 0 0001157601 MADRIGAL PHARMACEUTICALS, INC. MDGL 0001518611 Sibold William John C/O MADRIGAL PHARMACEUTICALS, INC. 200 BARR HARBOR DRIVE, SUITE 200 WEST CONSHOHOCKEN PA 19428 1 1 0 0 President and CEO 0 Common Stock 2026-01-26 4 S 0 1577 492.42 D 148497 D This sale represents the number of shares sold by the Issuer on behalf of the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. This sale was automatic and not at the discretion of the Reporting Person. /s/ Mardi Dier, as Attorney-in-Fact 2026-01-26