X0508 4 2026-01-20 0 0001357874 PRECISION BIOSCIENCES INC DTIL 0001830874 Amoroso Michael C/O PRECISION BIOSCIENCES, INC. 302 E. PETTIGREW STREET, SUITE A-100 DURHAM NC 27701 1 1 0 0 President and CEO 1 Common Stock 2026-01-20 4 M 0 8888 A 124463 D Common Stock 2026-01-20 4 M 0 37069 A 161532 D Common Stock 2026-01-20 4 M 0 69421 A 230953 D Common Stock 2026-01-22 4 S 0 34799 4.17 D 196154 D Restricted Stock Units 2026-01-20 4 M 0 8888 0 D Common Stock 8888 0 D Restricted Stock Units 2026-01-20 4 M 0 37069 0 D Common Stock 37069 37069 D Restricted Stock Units 2026-01-20 4 M 0 69421 0 D Common Stock 69421 69421 D Represents the vesting of Restricted Stock Units ("RSUs") on January 20, 2026. Each RSU represents a contingent right to receive one share of the Issuer's Common Stock. The sales were effected pursuant to a Rule 10b5-1 plan adopted on August 2, 2024. The transaction was a sell-to-cover, with shares only sold to cover tax withholding obligations in connection with the vesting and settlement of RSUs. The Reporting Person did not sell or otherwise dispose of shares reported on this Form 4 for any reason other than to cover required taxes and fees. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $3.97 to $4.30. The Reporting Person undertakes to provide the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote On January 20, 2023 the Reporting Person was granted RSUs, which vested in three substantially equal annual installments beginning on January 20, 2024, subject to the Reporting Person's continued service to the Issuer through the applicable vesting dates. On April 18, 2024 the Reporting Person was granted RSUs, which vest in three substantially equal annual installments beginning on January 20, 2025, subject to the Reporting Person's continued service to the Issuer through the applicable vesting dates. On August 22, 2024 the Reporting Person was granted RSUs, which vest in three substantially equal annual installments beginning on January 20, 2025, subject to the Reporting Person's continued service to the Issuer through the applicable vesting dates. /s/ Dario Scimeca, Attorney-in-Fact for Michael Amoroso 2026-01-22