X0508 4 2026-01-20 0 0001357874 PRECISION BIOSCIENCES INC DTIL 0001770169 SMITH J. JEFFERSON C/O PRECISION BIOSCIENCES, INC. 302 E. PETTIGREW STREET, SUITE A-100 DURHAM NC 27701 0 1 0 0 Chief Research Officer 1 Common Stock 2026-01-20 4 M 0 2500 A 93718 D Common Stock 2026-01-20 4 M 0 10447 A 104165 D Common Stock 2026-01-21 4 M 0 16219 A 120384 D Common Stock 2026-01-21 4 S 0 10200 4.03 D 110184 D Common Stock 7931 I By Charitable Remainder Unitrust Restricted Stock Units 2026-01-20 4 M 0 2500 0 D Common Stock 2500 0 D Restricted Stock Units 2026-01-20 4 M 0 10447 0 D Common Stock 10447 10447 D Restricted Stock Units 2026-01-20 4 M 0 16219 0 D Common Stock 16219 16219 D Represents the vesting of Restricted Stock Units ("RSUs") on January 20, 2026. Each RSU represents a contingent right to receive one share of the Issuer's Common Stock. Includes 3,413 shares acquired under the Issuer's 2019 Employee Stock Purchase Plan at a weighted average price per share of $5.74 The sales were effected pursuant to a Rule 10b5-1 plan adopted on April 25, 2024. The transaction was a sell-to-cover, with shares only sold to cover tax withholding obligations in connection with the vesting and settlement of RSUs. The Reporting Person did not sell or otherwise dispose of shares reported on this Form 4 for any reason other than to cover required taxes and fees. On January 20, 2023 the Reporting Person was granted RSUs, which vested in three substantially equal annual installments beginning on January 20, 2024, subject to the Reporting Person's continued service to the Issuer through the applicable vesting dates. On April 18, 2024 the Reporting Person was granted RSUs, which vest in three substantially equal annual installments beginning on January 20, 2025, subject to the Reporting Person's continued service to the Issuer through the applicable vesting dates. On August 22, 2024 the Reporting Person was granted RSUs, which vest in three substantially equal annual installments beginning on January 20, 2025, subject to the Reporting Person's continued service to the Issuer through the applicable vesting dates. /s/ Dario Scimeca Attorney-in-fact for Jeff Smith 2026-01-22