X0508 4 2026-01-16 0 0001576885 Acumen Pharmaceuticals, Inc. ABOS 0002009718 Doherty James J. C/O ACUMEN PHARMACEUTICALS, INC. 1210-1220 WASHINGTON STREET, SUITE 210 NEWTON MA 02465 0 1 0 0 President and CDO 0 Common Stock 2026-01-16 4 A 0 166867 0 A 220900 D Employee Stock Option (right to buy) 1.89 2026-01-16 4 A 0 250300 0 A 2036-01-16 Common Stock 250300 250300 D Represents a restricted stock unit ("RSU") award. Each RSU represents a contingent right to receive one share of the Issuer's Common Stock. The RSUs will vest in three equal annual installments commencing one year after the grant date, subject to the Reporting Person's continuous service through each such vesting date. The shares subject to the option will vest in 48 equal monthly installments such that the option is fully vested on the fourth anniversary of the date of grant, subject to the Reporting Person's continuous service through each such vesting date. /s/ Derek Meisner, Attorney-in-Fact 2026-01-21