X0508 4 2026-01-20 0 0001157601 MADRIGAL PHARMACEUTICALS, INC. MDGL 0002034056 Kelley Shannon T C/O MADRIGAL PHARMACEUTICALS, INC. 200 BARR HARBOR DRIVE, SUITE 200 WEST CONSHOHOCKEN PA 19428 0 1 0 0 General Counsel 1 Common Stock 2026-01-20 4 S 0 263 490.77 D 8910 D Common Stock 2026-01-20 4 S 0 429 501.40 D 8481 D This sale represents the number of shares sold by the Issuer on behalf of the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. This sale was automatic and not at the discretion of the Reporting Person. This sale was made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 7, 2024. /s/ Mardi Dier, as Attorney-in-Fact 2026-01-20