X0508 4 2026-01-15 0 0001157601 MADRIGAL PHARMACEUTICALS, INC. MDGL 0002105550 Thakkar Rita C/O MADRIGAL PHARMACEUTICALS, INC. 200 BARR HARBOR DRIVE, SUITE 200 WEST CONSHOHOCKEN PA 19428 0 1 0 0 Chief Accounting Officer 0 Common Stock 2026-01-15 4 A 0 2398 0 A 2398 D Stock Option (Right to Buy) 495.88 2026-01-15 4 A 0 1826 0 A 2036-01-15 Common Stock 1826 1826 D Represents a grant of restricted stock units, which vest as to 25% of the shares on each of January 15, 2027, January 15, 2028, January 15, 2029 and January 15, 2030, provided the Reporting Person continues in service with the Issuer on each such date. The option vests as to 25% of the shares on the first anniversary of the date of grant (January 15, 2027) and, thereafter, 6.25% of the shares shall vest on the last day of each successive three-month period, provided the Reporting Person continues in service with the Issuer on each such date. /s/ Mardi Dier, as Attorney-in-Fact 2026-01-20