X0508 4 2026-01-09 0 0001157601 MADRIGAL PHARMACEUTICALS, INC. MDGL 0001236927 FRIEDMAN PAUL A C/O MADRIGAL PHARMACEUTICALS, INC. 200 BARR HARBOR DRIVE, SUITE 400 WEST CONSHOHOCKEN PA 19428 1 0 0 0 1 Common Stock 2026-01-09 4 M 0 24520 15.80 A 211684 D Common Stock 2026-01-09 4 S 0 1480 511.9774 D 210204 D Common Stock 2026-01-09 4 S 0 1094 513.1079 D 209110 D Common Stock 2026-01-09 4 S 0 1345 514.681 D 207765 D Common Stock 2026-01-09 4 S 0 1996 515.8123 D 205769 D Common Stock 2026-01-09 4 S 0 766 516.8356 D 205003 D Common Stock 2026-01-09 4 S 0 2450 517.8591 D 202553 D Common Stock 2026-01-09 4 S 0 1363 518.6837 D 201190 D Common Stock 2026-01-09 4 S 0 846 519.8838 D 200344 D Common Stock 2026-01-09 4 S 0 681 521.0327 D 199663 D Common Stock 2026-01-09 4 S 0 840 521.9779 D 198823 D Common Stock 2026-01-09 4 S 0 970 522.9972 D 197853 D Common Stock 2026-01-09 4 S 0 1199 524.0986 D 196654 D Common Stock 2026-01-09 4 S 0 2432 525.0475 D 194222 D Common Stock 2026-01-09 4 S 0 1066 526.0005 D 193156 D Common Stock 2026-01-09 4 S 0 1560 526.9685 D 191596 D Common Stock 2026-01-09 4 S 0 575 528.1777 D 191021 D Common Stock 2026-01-09 4 S 0 691 529.1654 D 190330 D Common Stock 2026-01-09 4 S 0 166 529.7624 D 190164 D Common Stock 2026-01-09 4 S 0 280 530.6871 D 189884 D Common Stock 2026-01-09 4 S 0 80 532.50 D 189804 D Common Stock 2026-01-09 4 S 0 332 534.1638 D 189472 D Common Stock 2026-01-09 4 S 0 148 535.2886 D 189324 D Common Stock 2026-01-09 4 S 0 473 536.0206 D 188851 D Common Stock 2026-01-09 4 S 0 487 536.8768 D 188364 D Common Stock 2026-01-09 4 S 0 80 537.845 D 188284 D Common Stock 2026-01-09 4 S 0 480 539.2317 D 187804 D Common Stock 2026-01-09 4 S 0 600 540.358 D 187204 D Common Stock 2026-01-09 4 S 0 40 545.79 D 187164 D Common Stock 655540 I By SQN LLC Stock Option (Right to Buy) 15.80 2026-01-09 4 M 0 24520 0 D 2027-03-02 Common Stock 24520 280 D These sales were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 10, 2025. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $511.71 to $512.51, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote and the footnotes below. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $512.77 to $513.60, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $514.28 to $515.22, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $515.29 to $516.21, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $516.34 to $517.28, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $517.36 to $518.35, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $518.38 to $519.37, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $519.45 to $520.42, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $520.48 to $521.45, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $521.49 to $522.40, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $522.49 to $523.46, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $523.51 to $524.48, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $524.51 to $525.49, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $525.55 to $526.50, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $526.56 to $527.51, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $527.56 to $528.53, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $528.56 to $529.52, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $529.56 to $530.12, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $530.63 to $531.03, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $533.60 to $534.54, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $534.60 to $535.57, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $535.62 to $536.57, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $536.64 to $537.11, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $537.83 to $537.86, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $539.00 to $539.42, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $540.25 to $540.38, inclusive. The Reporting Person and his spouse are each managing members of SQN, LLC. The Reporting Person disclaims beneficial ownership of these securities except to the extent of his pecuniary interest therein, if any, and the inclusion of these shares in this report shall not be deemed an admission of the beneficial ownership of all of the reported shares for purposes of Section 16 or for any other purpose. The shares underlying this stock option are fully vested and exercisable. /s/ Mardi Dier, as Attorney-in-Fact 2026-01-13