X0508 4 2025-12-15 0 0001253689 CRESCENT BIOPHARMA, INC. CBIO 0002074223 Doughty Christopher Grant C/O CRESCENT BIOPHARMA, INC. 300 FIFTH AVENUE WALTHAM MA 02451 0 1 0 0 Chief Business Officer 0 Ordinary Shares 2025-12-15 4 A 0 14714 A 54194 D Ordinary Shares 2025-12-15 4 A 0 8000 A 62194 D Stock Option (Right to Buy) 13.21 2025-12-15 4 A 0 58855 0 A 2035-12-15 Ordinary Shares 58855 58855 D Represents an award of Restricted Stock Units ("RSUs"). Each RSU represents a contingent right to receive one share of the Issuer's Ordinary Shares. The RSUs shall vest in approximately equal three-month installments through the four-year anniversary of December 15, 2025, subject to the Reporting Person remaining continuously employed by or providing services to the Issuer or its subsidiaries from December 15, 2025 through each such vesting date. This Option represents a right to purchase shares of the Issuer's Ordinary Shares and vests with respect to 1/48th of the Option on each monthly anniversary of December 15, 2025, subject to the Reporting Person remaining continuously employed by or providing services to the Issuer or its subsidiaries from December 15, 2025 through each such vesting date. /s/ Barbara Bispham, as attorney-in-fact for Christopher Doughty 2025-12-17