X0508 4 2025-12-09 0 0001396814 Pacira BioSciences, Inc. PCRX 0001734779 Cross Shawn C/O PACIRA BIOSCIENCES, INC. 2000 SIERRA POINT PARKWAY, SUITE 900 BRISBANE CA 94005 0 1 0 0 Chief Financial Officer 1 Common Stock 2025-12-09 4 M 0 15896 16.45 A 72146 D Common Stock 2025-12-09 4 S 0 15896 25.03 D 56250 D Common Stock 2025-12-10 4 M 0 9104 16.45 A 65354 D Common Stock 2025-12-10 4 S 0 9104 25.14 D 56250 D Stock Option (Right to Buy) 16.45 2025-12-09 4 M 0 15896 0 D 2034-11-04 Common Stock 15896 184104 D Stock Option (Right to Buy) 16.45 2025-12-10 4 M 0 9104 0 D 2034-11-04 Common Stock 9104 175000 D The option exercises and sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan previously adopted by the reporting person in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $25.00 to $25.11, inclusive. The reporting person undertakes to provide to the issuer, any shareholder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnotes 2 and 3. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $25.00 to $25.30, inclusive. The stock option vested and became exercisable as to 25% of the option shares on the first anniversary of the grant date, and vests as to the remaining shares in successive equal quarterly installments over the subsequent three years, provided that the reporting person remains in continuous service with the issuer as of each vesting date. /s/ Kristen Williams, Attorney-in-Fact 2025-12-11