X0508 4 2025-12-02 0 0001157601 MADRIGAL PHARMACEUTICALS, INC. MDGL 0001574591 Dier Mardi C/O MADRIGAL PHARMACEUTICALS, INC. 200 BARR HARBOR DRIVE, SUITE 200 WEST CONSHOHOCKEN PA 19428 0 1 0 0 EVP and CFO 1 Common Stock 2025-12-02 4 M 0 4173 251.63 A 14613 D Common Stock 2025-12-02 4 S 0 320 570.386 D 14293 D Common Stock 2025-12-02 4 S 0 410 571.9892 D 13883 D Common Stock 2025-12-02 4 S 0 354 573.0151 D 13529 D Common Stock 2025-12-02 4 S 0 717 574.0011 D 12812 D Common Stock 2025-12-02 4 S 0 120 574.9524 D 12692 D Common Stock 2025-12-02 4 S 0 240 576.1517 D 12452 D Common Stock 2025-12-02 4 S 0 320 577.8144 D 12132 D Common Stock 2025-12-02 4 S 0 258 578.831 D 11874 D Common Stock 2025-12-02 4 S 0 480 579.8525 D 11394 D Common Stock 2025-12-02 4 S 0 240 585.4383 D 11154 D Common Stock 2025-12-02 4 S 0 240 587.8495 D 10914 D Common Stock 2025-12-02 4 S 0 160 589.6479 D 10754 D Common Stock 2025-12-02 4 S 0 160 590.3725 D 10594 D Common Stock 2025-12-02 4 S 0 74 595.2047 D 10520 D Common Stock 2025-12-02 4 S 0 80 596.185 D 10440 D Stock Option (Right to Buy) 251.63 2025-12-02 4 M 0 4173 0 D 2034-03-01 Common Stock 4173 9180 D These sales were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 2, 2025. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $570.17 to $570.77, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote and the footnotes below. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $571.45 to $572.34, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $572.48 to $573.38, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $573.59 to $574.44, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $574.67 to $575.24, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $575.69 to $576.46, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $577.36 to $578.31, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $578.37 to $579.20, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $579.59 to $580.46, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $585.08 to $585.99, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $587.58 to $588.07, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $589.13 to $589.96, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $590.15 to $590.58, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $595.18 to $595.41, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $596.18 to $596.19, inclusive. All shares issued pursuant to the exercise of the options reported herein represent 4,173 shares underlying an overall option award of 13,353 shares. All exercised options had vested. As to the overall option for 13,353 shares, 25% of the shares vested on March 1, 2025, and, thereafter, 6.25% of the shares vested or will vest on the last day of each successive three-month period, provided the Reporting Person continues in service with the Issuer on each such date. /s/ Mardi Dier 2025-12-03