X0508 4 2025-11-21 0 0001157601 MADRIGAL PHARMACEUTICALS, INC. MDGL 0002001571 Huntsman Carole C/O MADRIGAL PHARMACEUTICALS, INC. 200 BARR HARBOR DRIVE, SUITE 200 WEST CONSHOHOCKEN PA 19428 0 1 0 0 Chief Commercial Officer 1 Common Stock 2025-11-21 4 S 0 894 550.97 D 11096 D Common Stock 2025-11-21 4 S 0 144 547.2683 D 10952 D Common Stock 2025-11-21 4 S 0 120 548.71 D 10832 D Common Stock 2025-11-21 4 S 0 40 549.3425 D 10792 D Common Stock 2025-11-21 4 S 0 200 552.384 D 10592 D Common Stock 2025-11-21 4 S 0 40 553.2283 D 10552 D Common Stock 2025-11-21 4 S 0 120 556.04 D 10432 D Common Stock 2025-11-21 4 S 0 200 559.598 D 10232 D Common Stock 2025-11-21 4 S 0 80 560.62 D 10152 D Common Stock 2025-11-21 4 S 0 40 563.21 D 10112 D Common Stock 2025-11-21 4 S 0 80 564.565 D 10032 D The sale reported on this line represents the number of shares sold by the Issuer on behalf of the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. This sale was automatic and not at the discretion of the Reporting Person. These sales were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 5, 2024. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $547.12 to $547.42, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote and the footnotes below. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $548.25 to $548.94, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $549.30 to $549.38, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $551.96 to $552.81, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $553.22 to $553.23, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $555.74 to $556.19, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $559.22 to $560.06, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $560.24 to $561.00, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $564.55 to $564.58, inclusive. /s/ Mardi Dier, as Attorney-in-Fact 2025-11-21