X0508 4 2025-11-12 0 0001104506 INSMED Inc INSM 0001401017 Schaeffer Orlov S Nicole 700 US HIGHWAY 202/206 BRIDGEWATER NJ 08807 0 1 0 0 Chief People Strategy Officer 0 Common Stock 2025-11-12 4 M 0 30000 26.46 A 66461 D Common Stock 2025-11-12 4 S 0 4078 192.45 D 62383 D Common Stock 2025-11-12 4 S 0 6575 193.64 D 55808 D Common Stock 2025-11-12 4 S 0 19183 194.44 D 36625 D Common Stock 2025-11-12 4 S 0 164 195.88 D 36461 D Stock Option (right to buy) 26.46 2025-11-12 4 M 0 30000 0 D 2031-05-12 Common Stock 30000 15760 D This is the weighted average sales price representing 4,078 shares sold at prices ranging from $192.00 to $192.95 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request. This is the weighted average sales price representing 6,575 shares sold at prices ranging from $193.02 to $194.01 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request. This is the weighted average sales price representing 19,183 shares sold at prices ranging from $194.02 to $194.95 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request. This is the weighted average sales price representing 164 shares sold at prices ranging from $195.42 to $195.96 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request. The options became exercisable based on the following vesting schedule: 25% vested on the first anniversary of the grant date and an additional 12.5% vested on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant. All options are currently exercisable. /s/ S. Nicole Schaeffer, by Michael A. Smith as Attorney-in-fact 2025-11-14