X0508 4 2025-11-07 0 0001655759 ARVINAS, INC. ARVN 0001959410 Loomis David K C/O ARVINAS, INC. 5 SCIENCE PARK, 395 WINCHESTER AVE. NEW HAVEN CT 06511 0 1 0 0 Chief Accounting Officer 0 Common Stock 2025-11-07 4 S 0 230 9.89 D 31697 D This sale was made automatically by the Issuer to cover tax withholding obligations in connection with the vesting and settlement of 25% of the reporting person's restricted stock units (RSUs) granted on December 13, 2022. Includes an aggregate of 1,239 shares of common stock of the issuer previously purchased under and in accordance with the 2018 Employee Stock Purchase Plan of the issuer in transactions exempt under Rule 16b-3. /s/ Christina Bailey, as attorney-in-fact for David K. Loomis 2025-11-07