X0508 4 2025-11-02 0 0001357874 PRECISION BIOSCIENCES INC DTIL 0001830874 Amoroso Michael C/O PRECISION BIOSCIENCES, INC. 302 E. PETTIGREW STREET, SUITE A-100 DURHAM NC 27701 1 1 0 0 President and CEO 1 Common Stock 2025-11-02 4 M 0 9444 0 A 118984 D Common Stock 2025-11-03 4 S 0 3409 6.49 D 115575 D Restricted Stock Units 2025-11-03 4 M 0 9444 0 D Common Stock 9444 0 D Represents the vesting and settlement of Restricted Stock Units ("RSUs") on November 2, 2025. Each RSU represents a contingent right to receive one share of the Issuer's Common Stock. The sales were effected pursuant to a Rule 10b5-1 plan adopted on August 2, 2024. The transaction was a sell-to-cover, with shares only sold to cover tax withholding obligations in connection with the vesting and settlement of RSUs. The Reporting Person did not sell or otherwise dispose of shares reported on this Form 4 for any reason other than to cover required taxes and fees. On November 2, 2022 the Reporting Person was granted RSUs, which vest in three substantially equal annual installments beginning on November 2, 2023, subject to the Reporting Person's continued service to the Issuer through the applicable vesting dates. The RSUs vested in full on November 2, 2025. /s/ Dario Scimeca, Attorney-in-Fact for Michael Amoroso 2025-11-04