X0609 4 2026-08-21 0001628171 Revolution Medicines, Inc. RVMD 0001246842 GOLDSMITH MARK A false C/O REVOLUTION MEDICINES, INC. 700 SAGINAW DRIVE REDWOOD CITY CA 94063 true true false false See Remarks true Common Stock 2026-08-21 4 M false 80000 4.73 A 347330 D Common Stock 2026-08-21 4 S false 5128 207.2330 D 342202 D Common Stock 2026-08-21 4 S false 24917 208.3697 D 317285 D Common Stock 2026-08-21 4 S false 35938 209.2615 D 281347 D Common Stock 2026-08-21 4 S false 3813 210.2466 D 277534 D Common Stock 2026-08-21 4 S false 6583 211.3331 D 270951 D Common Stock 2026-08-21 4 S false 3621 212.0776 D 267330 D Common Stock 2026-08-21 4 S false 190 207.2454 D 64234 I Trust Common Stock 2026-08-21 4 S false 951 208.3648 D 63283 I Trust Common Stock 2026-08-21 4 S false 1351 209.2812 D 61932 I Trust Common Stock 2026-08-21 4 S false 136 210.4017 D 61796 I Trust Common Stock 2026-08-21 4 S false 245 211.4651 D 61551 I Trust Common Stock 2026-08-21 4 S false 127 212.0635 D 61424 I Trust Common Stock 2026-08-21 4 S false 177 207.2515 D 64247 I Trust Common Stock 2026-08-21 4 S false 937 208.3609 D 63310 I Trust Common Stock 2026-08-21 4 S false 1405 209.2664 D 61905 I Trust Common Stock 2026-08-21 4 S false 126 210.4030 D 61779 I Trust Common Stock 2026-08-21 4 S false 229 211.4648 D 61550 I Trust Common Stock 2026-08-21 4 S false 126 212.0641 D 61424 I Trust Common Stock 594060 I Trust Stock Option (Right to Buy) 4.73 2026-08-21 4 M false 80000 0 D 2023-08-09 2029-08-08 Common Stock 80000 344085 D Transaction made pursuant to a 10b5-1 trading plan adopted by Mark A. Goldsmith on May 22, 2026. Includes 182,938 restricted stock units. This transaction was executed in multiple trades at prices ranging from $206.78 to $207.7750. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $207.79 to $208.78. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $208.80 to $209.78. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $209.80 to $210.75. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $210.81 to $211.77. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $211.82 to $212.74. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $206.78 to $207.73. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. Held by Jonathan Goldsmith Revocable Trust. This transaction was executed in multiple trades at prices ranging from $207.84 to $208.82. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $208.84 to $209.60. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $209.87 to $210.81. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $210.93 to $211.85. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $212.00 to $212.13. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. Held by Rebecca Goldsmith Revocable Trust. This transaction was executed in multiple trades at prices ranging from $207.80 to $208.77. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $208.80 to $209.63. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. Held by Mark A. Goldsmith and Anne E. Midler 2002 Revocable Living Trust. President and Chief Executive Officer /s/ Jack Anders, as attorney-in fact for Mark A. Goldsmith 2026-08-25