X0609 4 2026-06-16 0001628171 Revolution Medicines, Inc. RVMD 0001246842 GOLDSMITH MARK A false C/O REVOLUTION MEDICINES, INC. 700 SAGINAW DRIVE REDWOOD CITY CA 94063 true true See Remarks true Common Stock 2026-06-16 4 S 0 10020 156.1188 D 267330 D Common Stock 594060 I Trust Common Stock 64424 I Trust Common Stock 64424 I Trust Transaction made pursuant to a Rule 10b5-1 instruction letter adopted on May 31, 2023 to satisfy the Reporting Person's tax withholding obligation upon the vesting of restricted stock units ("RSUs") after July 15, 2023. This transaction was executed in multiple trades at prices ranging from $156.1105 to $156.8250. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. Includes 182,938 restricted stock units. Includes 652 shares acquired under the Issuer's Employee Stock Purchase Plan on May 31, 2026. Held by Mark A. Goldsmith and Anne E. Midler 2002 Revocable Living Trust. Held by Jonathan Goldsmith Revocable Trust. Held by Rebecca Goldsmith Revocable Trust. President and Chief Executive Officer /s/ Jack Anders, as attorney-in fact for Mark A. Goldsmith 2026-06-18