X0609 4 2026-04-15 0001628171 Revolution Medicines, Inc. RVMD 0001246842 GOLDSMITH MARK A false C/O REVOLUTION MEDICINES, INC. 700 SAGINAW DRIVE REDWOOD CITY CA 94063 true true See Remarks true Common Stock 2026-04-15 4 M 0 23244 4.09 A 299942 D Common Stock 2026-04-15 4 M 0 96756 4.73 A 396698 D Common Stock 2026-04-15 4 S 0 120000 150.0874 D 276698 D Common Stock 594060 I Trust Common Stock 64424 I Trust Common Stock 64424 I Trust Stock Option (Right to Buy) 4.09 2026-04-15 4 M 0 23244 0 D 2023-03-13 2029-03-12 Common Stock 23244 24464 D Stock Option (Right to Buy) 4.73 2026-04-15 4 M 0 96756 0 D 2023-08-09 2029-08-08 Common Stock 96756 424085 D Transaction made pursuant to a 10b5-1 trading plan adopted by Mark A. Goldsmith on December 19, 2024. Includes 201,150 restricted stock units. This transaction was executed in multiple trades at prices ranging from $150.00 to $150.64. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. Held by Mark A. Goldsmith and Anne E. Midler 2002 Revocable Living Trust. Held by Jonathan Goldsmith Revocable Trust. Held by Rebecca Goldsmith Revocable Trust. President and Chief Executive Officer /s/ Jack Anders, as attorney-in fact for Mark A. Goldsmith 2026-04-17