X0508 4 2026-03-01 0001628171 Revolution Medicines, Inc. RVMD 0001246842 GOLDSMITH MARK A C/O REVOLUTION MEDICINES, INC. 700 SAGINAW DRIVE REDWOOD CITY CA 94063 true true See Remarks true Common Stock 2026-03-01 4 A 0 57100 0 A 289569 D Common Stock 2026-03-02 4 M 0 30000 4.09 A 319569 D Common Stock 2026-03-02 4 S 0 700 98.1708 D 318869 D Common Stock 2026-03-02 4 S 0 3500 99.7572 D 315369 D Common Stock 2026-03-02 4 S 0 3620 100.7346 D 311749 D Common Stock 2026-03-02 4 S 0 21329 101.6023 D 290420 D Common Stock 2026-03-02 4 S 0 851 102.1994 D 289569 D Common Stock 594060 I Trust Common Stock 2026-03-02 4 S 0 100 98.31 D 67324 I Trust Common Stock 2026-03-02 4 S 0 400 100.1225 D 66924 I Trust Common Stock 2026-03-02 4 S 0 1700 101.4743 D 65224 I Trust Common Stock 2026-03-02 4 S 0 800 101.9983 D 64424 I Trust Common Stock 2026-03-02 4 S 0 100 98.29 D 67324 I Trust Common Stock 2026-03-02 4 S 0 600 100.1933 D 66724 I Trust Common Stock 2026-03-02 4 S 0 2100 101.6341 D 64624 I Trust Common Stock 2026-03-02 4 S 0 200 102.08 D 64424 I Trust Stock Option (Right to Buy) 102.02 2026-03-01 4 A 0 128600 0 A 2036-02-28 Common Stock 128600 128600 D Stock Option (Right to Buy) 4.09 2026-03-02 4 M 0 30000 0 D 2023-03-13 2029-03-12 Common Stock 30000 47708 D Includes 225,863 restricted stock units. Reflects the transfer of 24,010 shares to the Mark A. Goldsmith and Anne E. Midler 2002 Revocable Living Trust. Transaction made pursuant to a 10b5-1 trading plan adopted by Mark A. Goldsmith on December 19, 2024. This transaction was executed in multiple trades at prices ranging from $97.83 to $98.38. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $99.12 to $100.07. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $100.14 to $101.13. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $101.14 to $102.11. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $102.14 to $102.32. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. Held by Mark A. Goldsmith and Anne E. Midler 2002 Revocable Living Trust. Held by Jonathan Goldsmith Revocable Trust. This transaction was executed in multiple trades at prices ranging from $99.79 to $100.71. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $100.81 to $101.79. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $101.82 to $102.14. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. Held by Rebecca Goldsmith Revocable Trust. This transaction was executed in multiple trades at prices ranging from $99.80 to $100.71. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $101.07 to $102.02. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. One forty-eighth (1/48th) of the shares initially subject to the option will vest on each monthly anniversary measured from March 1, 2026 (the "Vesting Commencement Date"), so that 100% of the shares subject to the option will be fully vested and exercisable as of the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service through each vesting date. President and Chief Executive Officer /s/ Jack Anders, as attorney-in fact for Mark A. Goldsmith 2026-03-03