X0508 4 2025-12-16 0001628171 Revolution Medicines, Inc. RVMD 0001969082 Cislini Jeff C/O REVOLUTION MEDICINES, INC. 700 SAGINAW DRIVE REDWOOD CITY CA 94063 true General Counsel true Common Stock 2025-12-16 4 S 0 2688 76.8169 D 47884 D Transaction made pursuant to a Rule 10b5-1 instruction letter adopted on May 31, 2023 to satisfy the Reporting Person's tax withholding obligation upon the vesting of restricted stock units ("RSUs") after July 15, 2023. Includes 147 shares acquired under the Issuer's Employee Stock Purchase Plan on November 30, 2025. Includes 38,769 restricted stock units. /s/ Jack Anders, as Attorney-in-fact for Jeff Cislini 2025-12-18