X0609 4 2026-06-18 1 0001818331 GeneDx Holdings Corp. WGS 0001585017 Ryan Jason false C/O GENEDX HOLDINGS CORP. 333 LUDLOW ST., NORTH TOWER, 6TH FLOOR STAMFORD CT 06902 true false false false 0 Class A Common Stock 2026-06-18 4 M 0 3576 0 A 15480 D Class A Common Stock 103284 I By Jason Ryan 2024 GRAT Restricted Stock Unit 2026-06-18 4 M 0 3576 0 D Class A Common Stock 3576 0 D Each restricted stock unit ("RSU") represents a contingent right to receive 1 share of the Issuer's Class A Common Stock upon settlement for no consideration. The securities in this row are held directly by the Jason Ryan 2024 GRAT U/A DTD 11/7/2024, of which the Reporting Person is trustee and sole annuitant. The entire award vested or vests on the earlier of the: (i) date of the 2026 annual meeting of the Issuer's stockholders, or (ii) first anniversary of the grant date, subject to the Reporting Person's continued service to the Issuer through the vesting date. These RSUs do not have an expiration date; they either vest or are cancelled prior to the vesting date. /s/ Bridget Brown, Attorney-in-Fact 2026-06-23