X0508 4 2025-12-02 0 0001434647 ZEVRA THERAPEUTICS, INC. ZVRA 0001584516 Secor Alicia C/O ZEVRA THERAPEUTICS, INC. 1180 CELEBRATION BOULEVARD, SUITE 103 CELEBRATION FL 34747 1 0 0 0 0 Stock Option (right to buy) 8.17 2025-12-02 4 A 0 45000 0 A 2035-12-01 Common Stock 45000 45000 D The exercise price is equal to the closing price of the Issuer's common stock on the Nasdaq Global Select Market on the date of grant, December 2, 2025. The option will vest and become exercisable as follows: (1) in three equal installments on the each of the dates that are one day prior to the first three annual stockholder meetings occurring after the grant date, or (2) immediately prior to a Change in Control, subject in each case to the director's continued service on such vesting date. /s/ Timothy J. Sangiovanni, Attorney-in-Fact for Alicia Secor 2025-12-09