X0508 4 2025-11-25 0001070081 PTC THERAPEUTICS, INC. PTCT 0001578850 Almstead Neil Gregory C/O PTC THERAPEUTICS, INC. 500 WARREN CORPORATE CENTER DRIVE WARREN NJ 07059 false true false false CHIEF TECHNICAL OPS OFFICER 1 Common Stock 2025-11-25 4 M 0 2475 18.01 A 103100 D Common Stock 2025-11-25 4 S 0 911 82.63 D 102189 D Common Stock 2025-11-25 4 S 0 990 83.44 D 101199 D Common Stock 2025-11-25 4 S 0 574 84.67 D 100625 D Common Stock 2025-11-25 4 M 0 2020 33.02 A 102645 D Common Stock 2025-11-25 4 S 0 689 82.63 D 101956 D Common Stock 2025-11-25 4 S 0 862 83.35 D 101094 D Common Stock 2025-11-25 4 S 0 289 84.61 D 100805 D Common Stock 2025-11-25 4 S 0 180 85.17 D 100625 D Common Stock 2025-11-25 4 M 0 8410 18.01 A 109035 D Common Stock 2025-11-25 4 S 0 2790 82.82 D 106245 D Common Stock 2025-11-25 4 S 0 3663 83.41 D 102582 D Common Stock 2025-11-25 4 S 0 1757 84.56 D 100825 D Common Stock 2025-11-25 4 S 0 200 85.37 D 100625 D Common Stock 2025-11-25 4 M 0 47624 33.02 A 148249 D Common Stock 2025-11-25 4 S 0 13514 82.55 D 134735 D Common Stock 2025-11-25 4 S 0 21844 83.33 D 112891 D Common Stock 2025-11-25 4 S 0 9171 84.42 D 103720 D Common Stock 2025-11-25 4 S 0 3095 85.15 D 100625 D Common Stock 2025-11-25 4 M 0 11399 33.02 A 112024 D Common Stock 2025-11-25 4 S 0 3744 82.61 D 108280 D Common Stock 2025-11-25 4 S 0 4834 83.39 D 103446 D Common Stock 2025-11-25 4 S 0 2621 84.54 D 100825 D Common Stock 2025-11-25 4 S 0 200 85.34 D 100625 D Common Stock 6179 I By Spouse Stock Option (Right to Buy) 18.01 2025-11-25 4 M 0 2475 0 D 2028-01-02 Common Stock 2475 8410 D Stock Option (Right to Buy) 33.02 2025-11-25 4 M 0 2020 0 D 2029-01-21 Common Stock 2020 47624 D Stock Option (Right to Buy) 18.01 2025-11-25 4 M 0 8410 0 D 2028-01-02 Common Stock 8410 0 D Stock Option (Right to Buy) 33.02 2025-11-25 4 M 0 47624 0 D 2029-01-21 Common Stock 47624 0 D Stock Option (Right to Buy) 33.02 2025-11-25 4 M 0 11399 0 D 2029-01-21 Common Stock 11399 0 D This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on December 10, 2024. This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $82.00 to $82.98 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price. This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $83.00 to $83.96 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price. This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $84.00 to $84.97 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price. This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $82.00 to $82.98 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price. This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $83.00 to $83.96 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price. This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $84.00 to $84.97 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price. This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $85.16 to $85.17 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price. This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $82.00 to $82.99 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price. This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $83.00 to $83.97 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price. This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $84.00 to $84.83 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price. This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $85.33 to $85.41 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price. This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $81.85 to $82.94 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price. This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $82.95 to $83.94 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price. This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $83.95 to $84.92 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price. This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $85.00 to $85.37 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price. This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $82.00 to $82.99 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price. This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $83.00 to $83.94 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price. This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $84.00 to $84.97 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price. This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $85.33 to $85.34 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price. Currently exercisable. /s/ Avraham S. Adler, Attorney-in-Fact 2025-11-26