X0508 4 2025-11-24 0001070081 PTC THERAPEUTICS, INC. PTCT 0001578850 Almstead Neil Gregory C/O PTC THERAPEUTICS, INC. 500 WARREN CORPORATE CENTER DRIVE WARREN NJ 07059 false true false false CHIEF TECHNICAL OPS OFFICER 1 Common Stock 2025-11-24 4 M 0 1900 18.01 A 102525 D Common Stock 2025-11-24 4 S 0 1900 80.14 D 100625 D Common Stock 2025-11-24 4 M 0 1650 33.02 A 102275 D Common Stock 2025-11-24 4 S 0 1650 80.14 D 100625 D Common Stock 2025-11-24 4 M 0 4715 18.01 A 105340 D Common Stock 2025-11-24 4 S 0 4715 80.15 D 100625 D Common Stock 2025-11-24 4 M 0 21206 33.02 A 121831 D Common Stock 2025-11-24 4 S 0 21206 80.19 D 100625 D Common Stock 2025-11-24 4 M 0 6101 33.02 A 106726 D Common Stock 2025-11-24 4 S 0 6101 80.17 D 100625 D Common Stock 6179 I By Spouse Stock Option (Right to Buy) 18.01 2025-11-24 4 M 0 1900 0 D 2028-01-02 Common Stock 1900 15600 D Stock Option (Right to Buy) 33.02 2025-11-24 4 M 0 1650 0 D 2029-01-21 Common Stock 1650 70850 D Stock Option (Right to Buy) 18.01 2025-11-24 4 M 0 4715 0 D 2028-01-02 Common Stock 4715 10885 D Stock Option (Right to Buy) 33.02 2025-11-24 4 M 0 21206 0 D 2029-01-21 Common Stock 21206 49644 D Stock Option (Right to Buy) 33.02 2025-11-24 4 M 0 6101 0 D 2029-01-21 Common Stock 6101 11399 D This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on December 10, 2024. This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $80.00 to $80.55 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price. This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $80.14 to $80.48 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price. This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $80.00 to $80.68 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price. This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $80.00 to $80.88 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price. This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $80.00 to $80.56 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price. Currently exercisable. /s/ Avraham S. Adler, Attorney-in-Fact 2025-11-26