X0508 4 2026-03-15 0 0001576280 Guardant Health, Inc. GH 0001562135 EAGLE CRAIG 3100 HANOVER STREET PALO ALTO CA 94304 0 1 0 0 Chief Medical Officer 0 Common Stock 2026-03-15 4 M 0 13712 0 A 72639 D Common Stock 2026-03-15 4 M 0 1402 0 A 74041 D Common Stock 2026-03-15 4 F 0 7661 85.49 D 66380 D Performance-Based Restricted Stock Units 0 2026-03-15 4 M 0 13712 0 D Common Stock 13712 0 D Restricted Stock Units 0 2026-03-15 4 M 0 1402 0 D Common Stock 1402 1402 D These shares were retained by the Company in order to meet the tax withholding obligations of the award-holder in connection with the vesting of an installment of the restricted stock units. The amount retained by the Company was not in excess of the amount of the tax liability. This represents a performance-based restricted stock unit award granted on June 7, 2023 with a 3-year performance metric. The second tranche metric was achieved and the shares vested on March 15, 2026. Not applicable for Restricted Stock Units. This represents a restricted stock unit award granted on June 9, 2023 that vests over a three-year period. 33% of the shares subject to such award vested on June 15, 2024 and the remaining 67% of the shares vests in equal quarterly installments over the remaining two-year period thereafter. /s/ John G. Saia, as attorney-in-fact for Craig Eagle 2026-03-17