X0508 4 2025-12-15 0 0000914475 NEUROCRINE BIOSCIENCES INC NBIX 0001533568 Norwalk Leslie V 6027 EDGEWOOD BEND CT. SAN DIEGO CA 92130 1 0 0 0 1 Common Stock 2025-12-15 4 M 0 8276 92.35 A 10705 D Common Stock 2025-12-15 4 M 0 1724 84.95 A 12429 D Common Stock 2025-12-15 4 S 0 5000 152.2287 D 7429 D Common Stock 2025-12-16 4 S 0 1190 155.0911 D 6239 D Non-Qualified Stock Option 92.35 2025-12-15 4 M 0 8276 0 D 2031-05-19 Common Stock 8276 557 D Non-Qualified Stock Option 84.95 2025-12-15 4 M 0 1724 0 D 2032-05-18 Common Stock 1724 0 D The disposition reported in this Form 4 was effected by a broker pursuant to instructions set forth in a Rule 10b5-1 trading plan adopted by the Reporting Person on September 12, 2025. Additionally, Issuer policy restricts the Reporting Person from amending or otherwise modifying any 10b5-1 trading plan subsequent to adoption of the plan. Represents a weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $151.79 to $152.82. The Reporting Person has provided to the issuer, and will provide to any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. Represents a weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $155.09 to $155.40. The Reporting Person has provided to the issuer, and will provide to any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. The option was granted on May 19, 2021 and vested in 12 equal monthly installments beginning June 19, 2021. The option was granted on May 18, 2022 and vested in 12 equal monthly installments beginning June 18, 2022. /s/ Darin Lippoldt, Attorney-in-Fact 2025-12-17