X0609 4 2026-09-14 0 0001711279 Krystal Biotech, Inc. KRYS 0001532023 Gangolli Julian S false C/O KRYSTAL BIOTECH, INC. 2100 WHARTON STREET, SUITE 701 PITTSBURGH PA 15203 1 0 0 0 0 Stock Option (Right to Buy) 340.03 2026-09-14 4 A 0 1187 0 A 2036-09-13 Common Stock 1187 1187 D Restricted Stock Units 2026-09-14 4 A 0 471 0 A Common Stock 471 471 D The stock options vest in full on September 14, 2027, subject to continued service on the Company's Board of Directors through such date and to earlier vesting in certain circumstances described in the Company's Non-Employee Director Compensation Policy as in effect on the date of grant. Each restricted stock unit ("RSU") represents a contingent right to receive one share of the Company's common stock. The RSUs vest in full on September 14, 2027, subject to continued service on the Company's Board of Directors through such date and to earlier vesting in certain circumstances described in the Company's Non-Employee Director Compensation Policy as in effect on the date of grant. /s/ Krish Krishnan, as attorney-in-fact for Julian S. Gangolli 2026-09-16