X0609 4 2026-05-06 0 0001802768 Royalty Pharma plc RPRX 0001507678 Legorreta Pablo G. false C/O ROYALTY PHARMA PLC 110 E. 59TH STREET NEW YORK NY 10022 1 1 0 0 CEO, Chairman of the Board 0 Class A Ordinary Shares 2026-05-06 4 A 0 143821 0 A 1242604 D Class A Ordinary Shares 1040410 I By Legorreta Children 2002 Trust Class A Ordinary Shares 901590 I By GST-Exempt Legorreta 2012 Family Trust Class A Ordinary Shares 600000 I By Legorreta 2023 SR Trust Class A Ordinary Shares 460139 I By Legorreta Investments LLC Class A Ordinary Shares 292190 I By Tata MC 35 Ltd. Class A Ordinary Shares 123310 I By IRRA Class A Ordinary Shares 118500 I By SEP/IRA Class A Ordinary Shares 41306 I By GST-Exempt Legorreta 2020 Family Trust Class A Ordinary Shares 10000 I By Son Class A Ordinary Shares 10000 I By Daughter Class A Ordinary Shares 6930 I By Spouse Reflects the exempt acquisition by the Reporting Person pursuant to Rule 16b-3 of Class A Ordinary Shares of the Issuer in connection with the settlement of Equity Performance Awards. In addition to the Class A Ordinary Shares disclosed above, the Reporting Person and family vehicles controlled by the Reporting Person hold limited partnership interests in RPI US Partners 2019, LP exchangeable into 73,495,660 Class A Ordinary Shares and Class E Ordinary Shares of Royalty Pharma Holdings Ltd ("RPH") exchangeable into 13,356,742 Class A Ordinary Shares. Class E Ordinary Shares of RPH are subject to vesting conditions. /s/ Sean Weisberg, as Attorney-in-Fact for Pablo G. Legorreta 2026-05-08