X0609 4 2026-10-06 0 0001357459 PALISADE BIO, INC. PALI 0001993292 Jones Mitchell Lawrence false C/O PALISADE BIO, INC. 4600 SOUTH SYRACUSE STREET, SUITE 900 DENVER CO 80237 0 1 0 0 See Remarks 0 Common Stock 2026-10-06 4 M 0 2620850 A 2714859 D Common Stock 2026-10-06 4 F 0 1031102 1.49 D 1683757 D Restricted Stock Units 2026-10-06 4 M 0 2555266 0 D Common Stock 2555266 5110534 D Restricted Stock Units 2026-10-06 4 M 0 65584 0 D Common Stock 65584 590249 D The shares were issued pursuant to settlement of vested Restricted Stock Units ("RSUs"). Represents the number of shares of common stock the Issuer has withheld to satisfy the Reporting Person's income tax withholding and remittance obligations as part of the settlement of vested RSUs. Accordingly, no shares of common stock will be sold in the public market to satisfy such income tax withholding and remittance obligations associated with the settlement of these vested RSUs. Each RSU represents a contingent right to receive one share of the Issuer's common stock. The RSUs shall vest with respect to 1/3rd of the shares on October 6, 2026 and quarterly thereafter over the following eight quarters, subject to the Reporting Person's continuous service to the Issuer through each such vesting date. The RSUs shall vest with respect to 1/6th of the shares on July 6, 2026 and quarterly thereafter over the following ten quarters, subject to the Reporting Person's continuous service to the Issuer through each such vesting date. President & Chief Medical Officer /s/ Ryker Willie, Attorney-in-Fact for Mitchell Lawrence Jones 2026-10-07