X0609 4 2026-07-01 0 0001335105 LIXTE BIOTECHNOLOGY HOLDINGS, INC. LIXT 0001569735 Felix Lourdes false 433 PLAZA REAL SUITE 275 BOCA RATON FL 33432 1 0 0 0 0 Common Stock 2026-07-01 4 A 0 30000 0 A 55000 D The reported transaction involved the Reporting Person's receipt of 30,000 restricted share units ("RSUs"). The RSUs were granted pursuant to the applicable RSU agreement and the Lixte Biotechnology Holdings, Inc. 2020 Stock Incentive Plan. Each RSU represents a contingent right to receive one share of common stock upon vesting, subject to continued service. The 30,000 RSUs vested upon the achievement of the performance conditions set forth in the Reporting Person's RSU agreement, which have been satisfied. The total reported in Column 5 includes (i) the 30,000 newly awarded RSUs, and (ii) 25,000 RSUs, all of which have vested. /s/ Lourdes Felix 2026-07-02