X0508 4 2026-02-09 0 0001357459 PALISADE BIO, INC. PALI 0001993292 Jones Mitchell Lawrence 1902 WRIGHT PLACE, SUITE 200 CARLSBAD CA 92008 0 1 0 0 Chief Medical Officer 0 Restricted Stock Units 2026-02-09 4 A 0 787000 0 A Common Stock 787000 787000 D Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of the Issuer's common stock, provided that, until such time as the Issuer has sufficient shares of Issuer common stock reserved under its 2021 Equity Incentive Plan to issue upon settlement of all outstanding grants thereunder, the RSUs may be settled upon vesting in cash. The RSUs shall vest with respect to 1/6th of the shares on July 6, 2026 and quarterly thereafter over the following 10 quarters, subject to the Reporting Person's continuous service to the Issuer through each such vesting date. /s/ Ryker Willie, Attorney-in-Fact 2026-02-11