X0508 4 2025-11-26 0 0001412486 Cocrystal Pharma, Inc. COCP 0000898860 FROST PHILLIP MD ET AL 4400 BISCAYNE BLVD MIAMI FL 33137-3227 1 0 1 0 0 Common Stock 2025-11-26 4 P 0 1500 1.00 A 1701051 I By Frost Gamma Investments Trust Common Stock 2025-11-26 4 P 0 2500 0.99 A 1703551 I By Frost Gamma Investments Trust Common Stock 27100 D These shares are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole stockholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is the sole stockholder of Frost-Nevada Corporation. The Reporting Person disclaims beneficial ownership of the securities held by Frost Gamma Investments Trust except to the extent of any pecuniary interest therein, and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose. Includes shares of common stock issuable upon vesting of restricted stock units. This Form 4 does not include any of the securities owned directly by OPKO Health, Inc., a company of which Dr. Frost is the Chairman of the Board and Chief Executive Officer, concerning the securities of which Dr. Frost does not hold voting and investment control. Dr. Frost disclaims beneficial ownership of the securities held by OPKO Health, Inc. except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that Dr. Frost is the beneficial owner of the securities for purposes of Section 16 or for any other purpose. /s/ Phillip Frost, MD ET AL 2025-11-28