X0508 4/A 2025-10-06 2025-10-08 0 0001357459 PALISADE BIO, INC. PALI 0001921045 Chuang Emil 1902 WRIGHT PLACE, SUITE 200 CARLSBAD CA 92008 1 0 0 0 0 Restricted Stock Units 2025-10-06 4 A 0 60600 0 A Common Stock 60600 60600 D Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of the Issuer's common stock, provided that, until such time as the Issuer has sufficient shares of Issuer common stock reserved under its 2021 Equity Incentive Plan (the "Plan") to issue upon settlement of all outstanding grants thereunder, the RSUs may be settled upon vesting in cash. This amended Form 4 is being filed to correct the previously reported grant amount of 510,700 RSUs to the Reporting Person. The Issuer has rescinded the grant of 450,100 RSUs of the previously reported grant of 510,700 RSUs. The RSUs are subject to a service-based vesting requirement and shall vest in three equal annual installments, with the first installment vesting on the earlier of (i) the date of the 2026 annual meeting of stockholders or (ii) the anniversary of October 6, 2025, subject to the Reporting Person's continuous service with the Issuer through such date. /s/ Ryker Willie, Attorney-in-Fact 2025-11-06