X0609 4 2026-03-26 0 0001847903 Centessa Pharmaceuticals plc CNTA 0001762176 Anderson Karen M. true C/O CENTESSA PHARMACEUTICALS PLC 3RD FL., 1 ASHLEY RD, ALTRINCHAM CHESHIRE X0 WA14 2DT UNITED KINGDOM 0 1 0 0 Chief People Officer 1 Ordinary Shares 2026-03-26 4 M 0 41076 8.01 A 103161 D Ordinary Shares 2026-03-26 4 S 0 41076 30.1242 D 62085 D Share Option (right to buy) 8.01 2026-03-26 4 M 0 41076 0 D 2034-02-01 Ordinary Shares 41076 83924 D The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share. The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 12, 2025. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $29.99 to $30.44, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range. 1/48th of the shares subject to such option shall vest and become exercisable in equal monthly installments with the first installment vesting on March 1, 2024. /s/ Raphael Deferiere, attorney-in-fact 2026-03-27