X0508 4 2026-02-01 0 0001847903 Centessa Pharmaceuticals plc CNTA 0002074392 Accardi Mario Alberto C/O CENTESSA PHARMACEUTICALS PLC 3RD FL., 1 ASHLEY RD, ALTRINCHAM CHESHIRE X0 WA14 2DT UNITED KINGDOM 1 1 0 0 Chief Executive Officer 0 Ordinary Shares 2026-02-01 4 F 0 2915 24.57 D 175886 D Ordinary Shares 2026-02-02 4 A 0 68000 0 A 243886 D Share Option (right to buy) 25.19 2026-02-02 4 A 0 273000 0 A 2036-02-02 Ordinary Shares 273000 273000 D The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share. Represents the number of shares withheld by the Issuer to cover tax withholding obligations in connection with the vesting of restricted share units. The shares reported in this transaction represent Restricted Share Units ("RSUs") issued under the Centessa Pharmaceuticals plc Amended and Restated 2021 Stock Option and Incentive Plan. Each RSU represents the contingent right to receive one Ordinary Share of the Issuer. The RSUs shall vest and be settled in four equal annual installments with the first such annual vesting being on February 2, 2027. 1/48th of the shares subject to such option shall vest and become exercisable in equal monthly installments with the first installment vesting on March 2, 2026. /s/ Raphael Deferiere, attorney-in-fact 2026-02-03