X0609 4 2026-07-09 0001527753 Personalis, Inc. PSNL 0001449535 Hall Christopher M false C/O PERSONALIS, INC. 6600 DUMBARTON CIRCLE FREMONT CA 94555 true true false false Chief Executive Officer 1 Common Stock 2026-07-09 4 M 0 100000 1.61 A 335986 D Common Stock 2026-07-09 4 S 0 100000 15.08 D 235986 D Stock Option (right to buy) 1.61 2026-07-09 4 M 0 66667 0 D 2034-03-15 Common Stock 66667 133333 D Stock Option (right to buy) 1.61 2026-07-09 4 M 0 33333 0 D 2034-03-15 Common Stock 33333 0 D The sales and option exercise reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 17, 2025. The price reported above reflects the weighted average price of the shares sold. The sale price ranged from $15.00 to $15.24 per share. Upon request from the SEC staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price within the range set forth in this Form 4. The option vested and became exercisable over the three-year period commencing April 15, 2024, with 1/36th of the shares subject to the option vesting each month of continuous service thereafter. The shares subject to the option are fully vested and exercisable. /s/ Aaron Tachibana, Attorney-in-Fact 2026-07-09