X0609 4 2026-06-10 0001806952 Lyell Immunopharma, Inc. LYEL 0001439368 Ramachandra Sumant false C/O LYELL IMMUNOPHARMA, INC. 201 HASKINS WAY, SUITE 101 SOUTH SAN FRANCISCO CA 94080 true false false false 0 Common Stock 10000 I Grantor and Trustee Option (right to buy) 13.22 2026-06-10 4 A 0 9250 0 A 2036-06-09 Common Stock 9250 9250 D On May 30, 2025, the Issuer effected a 1-for-20 reverse stock split of its common stock. All share and amounts reported herein reflect the reverse stock split. Shares held by the Sumant Ramachandra Rev Trust DTD 01/24/12. The Reporting Person is grantor and trustee of the Sumant Ramachandra Rev Trust DTD 01/24/12. The option shares shall vest on the earlier of (a) the date of the next annual meeting of the stockholders that occurs following June 10, 2026 (or the date immediately prior to such date if the Reporting Person's service as a director ends at such annual meeting due to the Reporting Person's failure to be reelected or the Reporting Person not standing for re-election); or (b) the first anniversary of June 10, 2026, subject to the Reporting Person providing continuous service through such date. /s/ Mark Meltz, Attorney-in-Fact 2026-06-11