X0609 4 2026-06-18 0 0001439222 AGIOS PHARMACEUTICALS, INC. AGIO 0001405288 FOUSE JACQUALYN A false C/O AGIOS PHARMACEUTICALS, INC. 88 SIDNEY STREET CAMBRIDGE MA 02139 1 0 0 0 0 Common stock 2026-06-18 4 M 0 2816 0 A 154156 D Restricted stock units 2026-06-18 4 M 0 2816 0 D Common stock 2816 0 D Restricted stock units 2026-06-18 4 A 0 2927 0 A Common stock 2927 2927 D Stock options (right to buy) 34.16 2026-06-18 4 A 0 14950 0 A 2036-06-18 Common stock 14950 14950 D Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock. The restricted stock units were granted on June 18, 2025. The shares underlying the stock units will vest in full on June 18, 2026. Vested shares will be delivered to the reporting person within three business days after such shares become vested. The restricted stock units were granted on June 18, 2026. The shares underlying the stock units will vest in full on June 18, 2027. Vested shares will be delivered to the reporting person within three business days after such shares become vested. These options were granted on June 18, 2026. The shares underlying these options vest as to 100% of the underlying shares on June 18, 2027. /s/ William Cook, as Attorney-in-fact for Jacqualyn Fouse 2026-06-23