X0609 4 2026-06-13 0 0001439222 AGIOS PHARMACEUTICALS, INC. AGIO 0001224108 CAPELLO JEFFREY D false C/O AGIOS PHARMACEUTICALS, INC. 88 SIDNEY STREET CAMBRIDGE MA 02139 1 0 0 0 0 Common stock 2026-06-13 4 M 0 1976 0 A 8049 D Restricted stock units 2026-06-13 4 M 0 1976 0 D Common stock 1976 0 D Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock. The restricted stock units were granted on June 13, 2023. Beginning on June 13, 2024, the shares underlying the stock units will vest in three equal annual installments. Vested shares will be delivered to the reporting person within three business days after such shares become vested. /s/ William Cook, as attorney-in-fact for Jeffrey Capello 2026-06-16