X0508 4 2026-01-05 0 0001439222 AGIOS PHARMACEUTICALS, INC. AGIO 0001957180 Milanova Tsveta C/O AGIOS PHARMACEUTICALS, INC. 88 SIDNEY STREET CAMBRIDGE MA 02139 0 1 0 0 Chief Commercial Officer 1 Common stock 2026-01-05 4 M 0 8475 0 A 37665 D Common stock 2026-01-05 4 S 0 2872 27.02 D 34793 D Restricted stock units 2026-01-05 4 M 0 8475 0 D Common stock 8475 0 D Shares sold to cover the tax withholding obligation in respect of vesting of the reporting person's restricted stock units. This transaction was effected pursuant to durable automatic sale instructions consistent with the affirmative defense to liability under Section 10(b) of the Securities Exchange Act of 1934 under Rule 10b5-1(c) promulgated under such Act. Such instructions were included in the reporting person's restricted stock unit agreement dated January 3, 2023. Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock. The restricted stock units were granted on January 3, 2023. Beginning on January 3, 2024, the shares underlying the restricted stock units will vest in three equal annual installments. /s/ William Cook, as Attorney in Fact for Tsveta Milanova 2026-01-07