X0508 4 2026-01-07 0001408443 Milestone Pharmaceuticals Inc. MIST 0001437782 Oliveto Joseph C/O MILESTONE PHARMACEUTICALS INC. 1111 DR. FREDERIK-PHILIPS BLVD, STE 420 MONTREAL A8 H4M 2X6 QUEBEC, CANADA true true false false President and CEO 1 Common Shares 2026-01-07 4 S 0 500 2.25 D 346721 D Common Shares 2026-01-08 4 S 0 43000 2.25 D 303721 D This transaction was made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 30, 2025. The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $2.25 to $2.265 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. /s/ Joseph Oliveto 2026-01-09