X0609 4 2026-09-30 0001645469 Monopar Therapeutics MNPR 0001727334 Robinson Chandler false 1000 SKOKIE BLVD SUITE 350 WILMETTE IL 60091 1 1 Chief Executive Officer 0 Common Stock 2026-09-30 4 M 0 9801 A 109068 D Common Stock 2026-09-30 4 F 0 4344 79.67 D 104724 D Common Stock 62815 I See Footnote Restricted Stock Unit 2026-09-30 4 M 0 9801 0 D Common Stock 9801 83602 D Represents shares acquired on vesting and settlement of restricted stock units. Represents shares withheld by the issuer to pay for the applicable withholding tax due upon vesting of restricted stock units. Represents shares held by the Chandler D. Robinson Irrevocable Trust U/A dated May 20, 2020. On February 1, 2023, the reporting person was granted 33,803 restricted stock units, vesting 6/48ths (4,225 shares) on June 30, 2023, and 3/48ths (2,113 shares) every 3 months thereafter until the RSU is fully vested on December 31, 2026. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. Disposed of restricted stock units were surrendered in exchange for issuance of common stock upon vesting and settlement. On March 4, 2025, the reporting person was granted 79,899 restricted stock units of which 6,002 shares vested immediately as of the grant date. The remaining 73,897 restricted stock units vest 6/48ths (9,237 shares) on June 30, 2025, and 3/48ths (4,619 shares) every 3 months thereafter until the RSU is fully vested on December 31, 2028. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. Disposed of restricted stock units were surrendered in exchange for issuance of common stock upon vesting and settlement. On December 2, 2025, the reporting person was granted 49,133 restricted stock units, vesting 6/48ths (6,142) on June 30, 2026, and 3/48ths (3,071 shares) every 3 months thereafter until the RSU is fully vested on December 31, 2029. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. Disposed of restricted stock units were surrendered in exchange for issuance of common stock upon vesting and settlement. /s/ Quan Vu, Attorney-in-fact 2026-10-02