X0508 4 2026-02-18 0001401667 PUMA BIOTECHNOLOGY, INC. PBYI 0001758507 NOUGUES MAXIMO F C/O PUMA BIOTECHNOLOGY, INC. 10880 WILSHIRE BLVD., SUITE 1700 LOS ANGELES CA 90024 1 Chief Financial Officer 0 Common Stock 2026-02-18 4 A 0 46739 0 A 240023 D Stock Option (Right to Buy) 6.68 2026-02-18 4 A 0 66541 0 A 2036-02-17 Common Stock 66541 66541 D Represents Restricted Stock Units ("RSUs") that shall vest with respect to one-fourth (1/4th) of the RSUs on each of July 1, 2026, January 1, 2027, July 1, 2027 and January 1, 2028, subject to the Reporting Person's continued service with the Company through the applicable vesting date. Options shall vest and become exercisable with respect to one-fourth (1/4th) of the shares subject thereto on each of July 1, 2026, January 1, 2027, July 1, 2027 and January 1, 2028, subject to the Reporting Person's continued service with the Company through the applicable vesting date. /s/ Gordon Esplin as attorney-in-fact for Maximo F. Nougues 2026-02-20