X0609 4 2026-10-10 0 0001434647 ZEVRA THERAPEUTICS, INC. ZVRA 0001681098 McFarlane Neil F. false C/O ZEVRA THERAPEUTICS, INC. 101 FEDERAL STREET BOSTON MA 02110 1 1 0 0 President and CEO 1 Common Stock 2026-10-10 4 M 0 50000 A 437225 D Common Stock 2026-10-12 4 S 0 20000 11.2474 D 417225 D Restricted Stock Unit 0 2026-10-10 4 M 0 50000 0 D Common Stock 50000 50000 D Each restricted stock unit ("RSU") represents a contingent right to receive one share of the Issuer's common stock. Adoption date of referenced 10b5-1(c) plan is: 03-25-2026 This transaction was executed in multiple trades at prices ranging from $11.07 to $11.36. The price reported reflects the weighted average sale price. The Reporting Person undertakes to provide upon request to the SEC staff, the Issuer or any security holder of the Issuer full information regarding the number of shares and prices at which the transaction was effected. 25% of the RSUs vested and settled on each of October 10, 2024, October 10, 2025 and October 10, 2026. The remaining 25% of the shares will vest on 10/10/2027, provided that at the relevant vesting date the Reporting Person's employment relationship has not been terminated as defined in the Issuer's 2023 Employment Inducement Award Plan. All shares will vest in full and become immediately exercisable upon a change of control of the Issuer or if the Reporting Person is terminated without cause or resigns for good reason. /s/ Timothy J. Sangiovanni, Attorney-in-Fact for Neil F. McFarlane 2026-10-13