X0508 4 2025-11-17 0 0001724521 Arcus Biosciences, Inc. RCUS 0001422996 Jaen Juan C. C/O ARCUS BIOSCIENCES, INC. 3928 POINT EDEN WAY HAYWARD CA 94545 0 1 0 0 President 1 Common Stock 2025-11-17 4 S 0 37114 20.2274 D 1049946 I By Trust Common Stock 2025-11-17 4 S 0 7836 20.713 D 1042110 I By Trust Common Stock 2025-11-18 4 S 0 5050 19.75 D 1037060 I By Trust Common Stock 367220 D The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 8, 2025. The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $19.65 to $20.645, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote. The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $20.65 to $20.82, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote. The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $19.48 to $20.17, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote. /s/ Carolyn Tang, Attorney-in-Fact 2025-11-19