X0609 4 2026-06-26 0001527753 Personalis, Inc. PSNL 0001401786 Tachibana Aaron false C/O PERSONALIS, INC. 6600 DUMBARTON CIRCLE FREMONT CA 94555 false true false false CFO AND COO 1 Common Stock 2026-06-26 4 M 0 28832 9.16 A 227665 D Common Stock 2026-06-26 4 M 0 22419 5.32 A 250084 D Common Stock 2026-06-26 4 S 0 51251 13.18 D 198833 D Stock Option (right to buy) 9.16 2026-06-26 4 M 0 28832 0 D 2029-03-13 Common Stock 28832 0 D Stock Option (right to buy) 5.32 2026-06-26 4 M 0 22419 0 D 2032-08-15 Common Stock 22419 7471 D The sales and option exercise reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on August 7, 2025. The price reported above reflects the weighted average price of the shares sold. The sale price ranged from $13.00 to $13.30 per share. Upon request from the SEC staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price within the range set forth in this Form 4. The shares subject to the option are fully vested and exercisable. /s/ Aaron Tachibana 2026-06-26