X0609 4 2026-10-06 0 0001299130 PACIFIC BIOSCIENCES OF CALIFORNIA, INC. PACB 0001384133 Gibson James R II false PACIFIC BIOSCIENCES OF CALIFORNIA, INC. 1305 O'BRIEN DRIVE MENLO PARK CA 94025 0 1 0 0 See Remarks 1 Common Stock 2026-10-06 4 M 0 500000 1.18 A 1745663 D Common Stock 2026-10-06 4 S 0 661815 3.108 D 1083848 D Stock Option (right to buy) 1.18 2026-10-06 4 M 0 500000 0 D 2026-03-31 2035-03-31 Common Stock 500000 1500000 D The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 22, 2026. This sale price represents the weighted average sale price of the shares sold ranging from $3.00 to $3.33 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price within the range set forth in this Form 4. 1/4th of the shares subject to the option vested on the one year anniversary of the date of grant, and the balance of shares vest monthly thereafter over the next three years, provided that the Reporting Person continues to serve through each vesting date. Chief Financial Officer /s/ Brett Atkins, Attorney-in-fact 2026-10-08