X0609 4 2026-05-11 0001806952 Lyell Immunopharma, Inc. LYEL 0001327111 Seely Lynn false C/O LYELL IMMUNOPHARMA, INC. 201 HASKINS WAY SOUTH SAN FRANCISCO CA 94080 true true false false President and CEO 0 Common Stock 2026-05-11 4 S 0 388 18.91 D 73878 D Shares automatically sold to cover tax withholding obligation from settlement of vested restricted stock units. The price reported above reflects the weighted average price of the shares sold. The sale price ranged from $18.91 to $19.15 per share. Upon request from the SEC staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price within the range set forth in this Form 4. /s/ Mark Meltz, Attorney-in-Fact 2026-06-15