X0609 4 2026-09-01 0 0001309108 WEX Inc. WEX 0001317498 Smith Melissa D false C/O WEX INC. 1 HANCOCK STREET PORTLAND ME 04101 1 1 0 0 CEO and President 1 Common Stock 2026-09-01 4 M 0 23187 104.95 A 149812 D Common Stock 2026-09-01 4 M 0 4922 99.69 A 154734 D Common Stock 2026-09-01 4 S 0 180 186.48 D 154554 D Common Stock 2026-09-01 4 S 0 9245 189.12 D 145309 D Common Stock 2026-09-01 4 S 0 7575 189.87 D 137734 D Common Stock 2026-09-01 4 S 0 11109 191.11 D 126625 D Common Stock 18277 I By husband Common Stock 1693 I FBC Irrevocable Trust Common Stock 1692 I BDC Irrevocable Trust Common Stock 1693 I GMC Irrevocable Trust Common Stock 42274 I Melissa D. Smith 2025 Trust Stock Option (right to buy) 104.95 2026-09-01 4 M 0 23187 0 D 2027-03-20 Common Stock 23187 0 D Stock Option (right to buy) 99.69 2026-09-01 4 M 0 4922 0 D 2027-05-10 Common Stock 4922 0 D The reported exercise of options and subsequent sale of shares occurred automatically pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on 6/2/2026. The reporting person exercised two stock option awards that were scheduled to expire on March 20, 2027 and May 10, 2027, respectively. The options would have been forfeited if not exercised prior to their respective expiration dates. Reflects distribution of 14,809 shares of common stock in accordance with the terms of the trust on August 28, 2026, from the Melissa D. Smith 2024 Trust, which are now directly held by the reporting person. The price listed is a weighted average price. These shares were sold for between $186.30 and $186.65, inclusive. Upon request, the reporting person will provide the Securities and Exchange Commission, WEX Inc. or any security holder of WEX Inc. with full information regarding the number of shares sold at each separate purchase price. The price listed is a weighted average price. These shares were sold for between $188.26 and $189.25, inclusive. The price listed is a weighted average price. These shares were sold for between $189.50 and $190.19, inclusive. The price listed is a weighted average price. These shares were sold for between $191.11 and $191.17, inclusive. This trust was first described in a Form 4 filed by the reporting person on 06/28/2022. This trust was first described in a Form 4 filed by the reporting person on 02/25/2026. This stock option vested with respect to one-third of these shares each on 03/20/2018, 03/20/2019, and 03/20/2020. Half of the performance based non-statutory stock options ("Performance-Based NSOs") reported on the reporting person's Form 4 dated May 12, 2017 (the "Original Form 4"), vested on June 26, 2020 when the Company's closing stock price was at least $149.54 for twenty consecutive trading days. Another quarter of the Performance-Based NSOs vested on December 29, 2020 when the Company's closing stock price was at least $174.45 for twenty consecutive trading days. The last remaining quarter of the Performance-Based NSOs vested on March 8, 2021 when the Company's closing stock price was at least $199.38 for twenty consecutive trading days. Please reference the Original Form 4 for further information regarding the vesting of the Performance-Based NSOs. /s/ Matthew Finkelstein, as attorney in-fact for Melissa D. Smith 2026-09-03