X0609 4 2026-05-11 0 0001388658 iRhythm Holdings, Inc. IRTC 0001316065 TALWALKAR ABHIJIT Y false C/O IRHYTHM HOLDINGS, INC. 699 8TH ST #600 SAN FRANCISCO CA 94103 1 0 0 0 1 Common Stock 2026-05-11 2026-05-11 4 P 0 5312 10.71 A 25611 D Common Stock 2026-05-11 2026-05-11 4 S 0 940 116.0542 D 24671 D Common Stock 2026-05-11 2026-05-11 4 S 0 642 116.9812 D 24029 D Common Stock 2026-05-11 2026-05-11 4 S 0 2293 118.0163 D 21736 D Common Stock 2026-05-11 2026-05-11 4 S 0 1147 119.1557 D 20589 D Common Stock 2026-05-11 2026-05-11 4 S 0 290 120.53 D 20299 D Employee Stock Option (right to buy) 10.71 2026-05-11 2026-05-11 4 M 0 5312 10.71 D 2016-06-23 2026-05-23 Common Stock 5312 0 D All transactions reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan established by Mr. Talwalkar on May 12, 2025. Represents the weighted-average sale price per share of a series of transactions, all of which were executed on May 11, 2026. The actual sale prices ranged from a low of $115.61 to a high of $116.61, inclusive. Mr. Talwalkar undertakes to provide upon request of the SEC staff, iRhythm Holdings, Inc. or any security holder of iRhythm Holdings, Inc., full information regarding the numbers of shares sold at each price within the range. The weighted-average sale price reflected has been rounded to 4 decimal points. Represents the weighted-average sale price per share of a series of transactions, all of which were executed on May 11, 2026. The actual sale prices ranged from a low of $116.62 to a high of $117.31, inclusive. Mr. Talwalkar undertakes to provide upon request of the SEC staff, iRhythm Holdings, Inc. or any security holder of iRhythm Holdings, Inc., full information regarding the numbers of shares sold at each price within the range. The weighted-average sale price reflected has been rounded to 4 decimal points. Represents the weighted-average sale price per share of a series of transactions, all of which were executed on May 11, 2026. The actual sale prices ranged from a low of $117.68 to a high of $118.45, inclusive. Mr. Talwalkar undertakes to provide upon request of the SEC staff, iRhythm Holdings, Inc. or any security holder of iRhythm Holdings, Inc., full information regarding the numbers of shares sold at each price within the range. The weighted-average sale price reflected has been rounded to 4 decimal points. Represents the weighted-average sale price per share of a series of transactions, all of which were executed on May 11, 2026. The actual sale prices ranged from a low of $118.70 to a high of $119.63, inclusive. Mr. Talwalkar undertakes to provide upon request of the SEC staff, iRhythm Holdings, Inc. or any security holder of iRhythm Holdings, Inc., full information regarding the numbers of shares sold at each price within the range. The weighted-average sale price reflected has been rounded to 4 decimal points. The option, originally granted on May 23, 2016 for 21,248 shares, vested in thirty-six equal monthly installments. This option has an expiration date of May 23, 2026. The Rule 10b5-1 trading plan of Mr. Talwalkar solely covers shares subject to options expiring in 2026 and 2027. /s/ Marc Rosenbaum, attorney-in-fact 2026-05-12